Low dose of fenoterol in treatment of moderate asthma crisis in children

Authors

DOI:

https://doi.org/10.51252/rsayb.v1i1.270

Keywords:

asthma crisis, cardiac alterations, fenoterol, lung function

Abstract

The effect of low doses of fenoterol in the treatment of moderate asthma crisis in children was evaluated through a quasi-experimental study in the Emergency Service of the Hospital Belén de Trujillo (HBT), September 2015 - August 2017. A population of 90 children between 4 and 14 years 11 months of age, of both sexes, with moderate asthmatic crisis; were randomly distributed into 3 groups, their initial lung function was measured by Peak Expiratory Flow (PEF), and groups I, II and III were nebulized every 20 minutes for one hour with fenoterol at conventional doses, 75% and 50% of doses respectively; lung function (PEF) and cardiac function (rhythm and rate) were assessed 10 minutes after each nebulization. The results were validated using the student's t test, with p<0.05 and the X2 test for group comparison with P <0.05. Ethical considerations were met for this type of study. The results found of variation of the PEF were comparable between Groups I, II and III (p> 0.05). But lower doses of fenoterol (group III) conditions significantly less heart rhythm alteration than Groups I and II (P <0.005). It was concluded that at low doses fenoterol promotes the recovery of lung function with slight alteration of cardiac function in children with moderate asthmatic crisis

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References

Jain D, Singal R, Jain G, Clark R. Understanding and managing acute severe and difficult asthma. J Indian Acad Clin Med. 2006;7(4):316–27.

Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention [Internet]. GINA; 2012. Available from: https://ginasthma.org/wp-content/uploads/2019/01/2012-GINA.pdf

Lezana V, Arancibia J. Consideraciones epidemiológicas del asma en Latinoamérica. Neumol pediátrica [Internet]. 2006;1(2):45–8. Available from: https://pesquisa.bvsalud.org/adolecbr/resource/pt/lil-497930

Ocampo J, Gaviria R, Sánchez J. Prevalencia del asma en América Latina. Mirada crítica a partir del ISAAC y otros estudios. Rev Alerg México. 2017; 64(2):188–97. https://doi.org/10.29262/ram.v64i2.256

National Asthma Education and Prevention Program. Guidelines for the Diagnosis and Management of Asthma 2007 [Internet]. 2007. Available from: https://www.nhlbi.nih.gov/sites/default/files/media/docs/asthsumm.pdf

Asensi Monzó M. Crisis de asma. Rev Pediatría Atención Primaria [Internet]. 2017;19(26):17–25. Available from: https://pap.es/articulo/12496/crisis-de-asma

Barranco Ruiz F. Principios de Urgencias, Emergencias y Cuidados Críticos. Editorial Alhulia; 1999.

Contreras Zuñiga E, Zuluaga Martínez S, Casa Quiroga I, Plaza Ramirez B. Patologías obstructivas de la vía aérea: Crisis asmática. Neumol Cir Torax. 2007; 66(4).

González Díaz S, Sienra Monge J, Huerta López J. Nuevas tendencias en el tratamiento del asma, -XXVII Congreso Nacional de Pediatría, mayo 2000. Alergia, asma e Inmunol pediátricas. 2000; 9(4):130–4.

Ladrón de Guevara Gainza C. Comportamiento de las Crisis Agudas de Asma Bronquial. Rev Electrónica Portales Médicos.com [Internet]. 2014;9(4):164. Available from: https://www.revista-portalesmedicos.com/revista-medica/crisis-agudas-de-asma-bronquial/

Alizo H, Borges A, Carvallo E, Gil V, Herrera L, Medran G. Clasificación y diagnóstico del asma. Rev Mex Ped. 1997; 1(4):8–15.

Akdis C, Agache I. Global Atlas of Asthma. European Academy of Allergy and Clinical Immunology; 2013.

Larenas-Linnemann D, Salas-Hernández J, Vázquez-García JC, Ortiz-Aldana FI, Fernández-Vega M, Del Río-Navarro BE, et al. Guía Mexicana del Asma: GUIMA 2017. Rev Alerg México. 2017; 64:s11–128. https://doi.org/10.29262/ram.v64i0.272

Steen B. Manejo de la crisis de asma en urgencias. Rev Patol Respir [Internet]. 2017;10(4). Available from: https://m.revistadepatologiarespiratoria.org/revistadepatologiarespiratoria_detalle_articulo.php?aid=291

Ministerio de Salud y Protección Social. Guías Básicas de Atención Médica Prehospitalaria. 2nd ed. Universidad de Antioquia; 2012.

Asociación Española de Pediatría. Protocolos diagnósticos y terapéuticos en Urgencias de Pediatría. 3rd ed. Sociedad Española de Urgencia de Pediatría; 2020.

Horak F, Doberer D, Eber E, Horak E, Pohl W, Riedler J, et al. Diagnosis and management of asthma – Statement on the 2015 GINA Guidelines. Wien Klin Wochenschr. 2016; 128(15–16):541–54. https://doi.org/10.1007/s00508-016-1019-4

López-Herce J, Calvo Rey C. Asma grave. Tratamiento farmacológico y asistencia respiratoria. Rev Española Pediatría. 2010; 66(1):48–59.

Huaman R, Velasco J, Vargas R, Diaz A, Garcia A, Chiarella P, et al. Efecto broncodilatador de fenoterol y salbutamol asociados a un corticoide en niños con crisis de asma. Rev Medica Hered. 2013; 7(1). https://doi.org/10.20453/rmh.v7i1.500

Gleiter CH. Fenoterol: Pharmacology and Clinical Use. Cardiovasc Drug Rev. 2006; 17(1):87–106. https://doi.org/10.1111/j.1527-3466.1999.tb00006.x

Chaustre I, Castro M, Rodulfo J, Bravo Sifontes C, Matute X. Diagnóstico del asma en el niño. Arch Venez Pueric Pediatr. 2010; 73(2):66–72.

Dirección General de Epidemiología. Boletín Epidemiológico Semanal [Internet]. 2021. Available from: https://www.dge.gob.pe/portalnuevo/publicaciones/boletines-epidemiologicos/

O’Donnell SR, Wanstall JC. Evidence that the efficacy (intrinsic activity) of fenoterol is higher than that of salbutamol on β-adrenoceptors in guinea-pig trachea. Eur J Pharmacol. 1978; 47(3):333–40. https://doi.org/10.1016/0014-2999(78)90241-8

Lemoine H, Overlack C, Koh A, Worth H, Reinhardt D. Formoterol, fenoterol, and salbutamol as partial agonists for relaxation of maximally contracted guinea pig tracheae: Comparison of relaxation with receptor binding. Lung. 1992; 170(3). https://doi.org/10.1007/BF00174319

Velasco J, Huaman Guerrero R, Vargas R, Diaz A, Chiarella P, Whu R. Dos esquemas terapéuticos en el manejo de crisis asmática en niños. Rev Medica Hered. 2015; 8(1):5. https://doi.org/10.20453/rmh.v8i1.2403

Calvo G. M, Marín H. F, Bilbao M. T, Calvo A. M. Estudio comparativo: fenoterol - cromoglicato vs. salbutamol - beclometasona en pacientes pediátricos con asma bronquial moderada. Rev Chil Enfermedades Respir [Internet]. 1994;10(1):34–44. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/lil-194560

Grupo de Farmacovigilancia de la red Panamericana para la Armonización Farmacéutica. Buenas Prácticas de Farmacovigilancia [Internet]. Organización Panamericana de la Salud; 2008. Available from: https://www.paho.org/hq/dmdocuments/2008/BPFv-de-las-Americas--5-nov.pdf

Herrera Comoglio R, Alesso L. Farmacovigilancia hacia una mayor seguridad en el uso de los medicamentos. 1st ed. Uppsala Monitoring Centre; 2012.

García-García JA, Reding-Bernal A, López-Alvarenga JC. Cálculo del tamaño de la muestra en investigación en educación médica. Investig en Educ Médica. 2013; 2(8):217–24. https://doi.org/10.1016/S2007-5057(13)72715-7

Vasquez Díaz P. Comparación de respuesta clínica de feneterol por nebulización y salbutamol en aerosol [Internet]. Universidad Peruana Cayetano Heredia; 1992. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/lil-107476#main_container

Herrera Gutiérrez L, Chiarella Ortigososo P, Cabanillas Lozada P. Eficacia de adrenalina y salbutamol nebulizados en el tratamiento de Bronquiolitis. Universidad Cayetano Heredia; 2005.

Alfonzo E, Gil A, Istúris G. Estudio comparativo de la eficacia del fenoterol y del bromuro de ipratropio en la crisis de asma en el niño. Gac Med Caracas [Internet]. 1989;97(4/6):111. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/lil-92051

Yuzuriha Yakabi J, Vega Briceño L, Chiarella Ortigosa P, Mormontoy Laurel W. Asma inducida por ejercicio, efecto preventivo de la asociación de sulfato de salbutamol y bromuro de ipratropio. Front en Med. 1999; 7(1):33.

Cañete R, Guilhem D, Brito K. Consentimiento informado: algunas consideraciones actuales. Acta Bioeth. 2012; 18(1):121–7. https://doi.org/10.4067/S1726-569X2012000100011

Magnussen H, Rabe K. The protective effect of low-dose inhaled fenoterol against methacholine and exercise-induced bronchoconstriction in asthma: A dose-response study. J Allergy Clin Immunol. 1992; 90(5):846–51. https://doi.org/10.1016/0091-6749(92)90111-E

Harries A, Laroche C, Britton M. Fenoterol solution via nebuliser--optimum dosage. Eur J Respir Dis. 1987; 71(5):334.

Elwood R, Abboud R. The short-term bronchodilator effects of fenoterol and ipratropium in asthma. J Allergy Clin Immunol. 1982; 69(5):467–73. https://doi.org/10.1016/0091-6749(82)90123-3

Rabe K, Jorres R, Magnussen H. The effect of 10, 50 and 200 mug inhaled fenoterol on exercise induced asthma. Clin Exp Allergy. 1993; 23(5):440–5. https://doi.org/10.1111/j.1365-2222.1993.tb00351.x

Published

2022-01-20

How to Cite

Herrera-Gutiérrez, L. A., Ugaz-Cayao, S. I., & González-Blas , M. V. . (2022). Low dose of fenoterol in treatment of moderate asthma crisis in children. Revista Salud amazónica Y Bienestar, 1(1), e270. https://doi.org/10.51252/rsayb.v1i1.270