Extracts and fitochemical components of Clibadium remotiflorum , Lonchocarpus nicou , Hura crepitans, Dieffenbachia costata, with therapeutical value against Leishmania, in vitro, San Martín
DOI:
https://doi.org/10.51252/rsayb.v1i2.347Keywords:
activity against Leishmania, extracts, phytocomponents, toxicityAbstract
The purpose of the present study was to evaluate the efficiency against Leishmaniasis of hydrolic and alcoholic extracts and phytocomponents obtained from the plants in the region San Martín with probably therapeutical value. Materials and Methods. Basic, experimental study, total alcoholic and hydrolic extracts and phytocomponents of Clibadium remotiflorum, Lonchocarpus nicou, Dieffenbachia costata and Hura crepitans were used and confronted to Leishmania peruviana and Leishmania braziliensis to evaluate its efficiency in vitro and to evaluate the toxicity of the extracts and phytocomponents with efficiency against Leishmaniasis using Artemia salina. Hydroalcoholic extracts and tanines, flavonoides, cumarines, saponines and alkaloids from plants in study were obtained. Hydroalcoholic extracts have activity against Leishmania peruviana and against Leishmania braziliensis.The flavonoides, alkaloids y cumarines present a higher toxicity and the tanines and saponines present limited activity; at the same time, they have a higher toxicity which evidence that an association between toxicity and anti-Leishmaniasis activity exists. The experiment in vivo in Mesocricetus auratus shows a promissory anti Leishmaniasis activity. Conclusions. Alcoholic and hydrolic extracts of Lonchocarpus nicou “barbasco”, Dieffenbachia costata “patquina”, Clibadium remotiflorum “huaca” and latex of Hura crepitans “catahua” have anti Leishmaniasis activity. The alkaloids, cumarines y flavonoides have higher anti Leishmaniasis activity. The toxicity of the hydroalcoholic and phytocomponents is considerable and it is necessary larger studies to determine the real therapeutical value of extracts and phytocomponents.
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